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Allan Leibowitz at Brown University, in Providence, Rhode Island, published a study which compared the effects of testosterone on the body of men with and without low-functioning adrenal glands in a small mouse model of the pituitary gland. The study showed that the male mice with low-functioning adrenal glands had lower testosterone levels than the control mice. It seemed that steroids acted to activate more genes involved in tissue repair and protein synthesis in the adrenal gland, as well as a more common muscle contraction mechanism in the body, . The most recent study of human subjects involves 12 men with low-functioning adrenal glands.
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